Profile

Title

Professor

Full name

Teresa K. Attwood

Affiliation

Faculty of Life Sciences & School of Computer Science
Michael Smith Building
The University of Manchester
Oxford Road, Manchester, UK

Working group 4

Executive Committee

Management Committee

Keywords

bioinformatics, protein sequence analysis, GPCRs, visualisation, data/tool interoperability

Publications

1. Attwood, T.K., Bradley, P., Flower, D.R., Gaulton, A., Maudling, N., Mitchell, A.L., Moulton, G., Nordle, A., Paine, K., Taylor, P., Uddin, A. & Zygouri, C. (2003) PRINTS and its automatic supplement, prePRINTS. Nucleic Acids Res, 31(1), 400-402.
2. Attwood, T.K. & Beck, M.E. (1994) 
PRINTS - A protein motif fingerprint database. Protein Engineering, 7(7), 841-848.
3. Mulder, N.J., Apweiler, R., Attwood, T.K., Bairoch, A., Binns, D., Bork, P., Cerutti, L., Copley, R., Courcelle, E., Das, U., Daugherty, L., Dibley, M., Finn, R., Fleischmann, W., Haft, D., Hulo, N., Hunter, S., Kanapin, A., Kejariwal, A., Labarga, A. (2007) New developments in the InterPro database. Nucleic Acids Res., 35, D224-D228.
4. Parry-Smith, D.J., Payne, A.W.R, Michie, A.D. & Attwood, T.K. (1998) 
HYPERLINK "http://www1.elsevier.com/journals/genecombis/jnl/articles/S0378111997006501/"CINEMA - A novel Colour INteractive Editor for Multiple Alignments. Gene, 221(1), GC57-63.
5. Mitchell, A.L., Reich, J.R. & Attwood, T.K. (2003) 
PRECIS - Protein Reports Engineered from Concise Information in SWISS-PROT. Bioinformatics, 19, 1664-1671.
6. Pettifer, S. et al. (2009) 
Visualising biological data: a semantic approach to tool and database integration.
BMC Bioinformatics, 10, S18.
7. Pettifer, S.R. et al. (2004) 
UTOPIA - User-friendly Tools for OPerating Informatics Applications.
Comparative and Functional Genomics, 5, CFG359.
8. Attwood, T.K. et al. (2009) Calling International Rescue - knowledge lost in literature and data landslide! Biochemical Journal, 424(3), 317-333.

Brief Description

The expertise of my research group lies, primarily, in computational protein sequence analysis. Seeking to diagnose structural, functional and family relationships of un-characterised proteins, I established the PRINTS(1,2) fingerprint database; with PROSITE, this was a founding partner of InterPro(3), now the world’s largest, unified protein family resource, playing a pivotal role in genome sequence annotation. I have also pioneered the design of tools to align and visualise protein sequences and structures (e.g., the CINEMA alignment editor(4)), and to annotate protein families (e.g., PRECIS(5) and MINOTAUR(a)). I have led a number of major projects, such as the EU EMBER(b) bioinformatics education consortium; the EPSRC PARADIGM Platform, which provided under-pinning funds for Manchester's bioinformatics groups; the EU BioMinT(c) text-mining consortium; and the BBSRC literature-mining project, MINOTAUR. I led the bioinformatics component of the EPSRC/DTI-funded UTOPIA(d) project to develop protein sequence and structure visualisation tools (6,7); I am also the Manchester PI on EU projects EMBRACE(e), on standards for bioinformatics data exchange, and IMPACT(f), on streamlining protein family annotation. I also lead the Semantic Biochemical Journal project, funded by Portland Press Limited(8), and the KTA Secondment Fellowship award funded by Pfizer, AstraZeneca and the EPSRC. I have been a Visiting Fellow at the European Bioinformatics Institute since 1997, where part of my group is still based.
a. http://www.bioinf.manchester.ac.uk/dbbrowser/minotaur/
b. http://www.ember.man.ac.uk/
c. http://www.pharmadm.com/biomint/org/
d. http://utopia.cs.man.ac.uk/
e. http://www.embracegrid.info/
f. http://www.project-impact.eu/

Contact Information

Phone

+44 (0) 161 275 5766

Fax

+44 (0) 161 275 5082

Email

attwood(at)bioinf(dot)man(dot)ac(dot)uk

History

Member for

3 years 32 weeks