Profile

Title

Chief Researcher

Full name

Aristidis S. Charonis

Affiliation

Biomedical Research Foundation of the Academy of Athens (BRFAA)

Working group 1

Working group 2

Management Committee

Keywords

fibrosis, diabetes, proteomics, kidney, LCM (Laser Capture Microdissection)

Publications

Anderson SS, Tsilibary EC and Charonis AS (1993). Nonenzymatic glycosylation induced modifications of intact tubular basement membrane. J.Clinical Invest. 92, 3045-3052

Chen Y, Krishnamurti U, Wayner E, Michael A and Charonis AS (1996). Receptors in proximal tubule epithelial cells for tubulointerstitial nephritis antigen (TIN-ag). Kidney Internat. 49, 153-157

Zhou B, Nelson TR, Kashtan C, Gleason B, Vlassi M, Michael AF and Charonis AS (2000). Identification of two alterantively spliced forms of human tubulointerstitial nephritis antigen (TIN-ag). Journal of the American Society of Nephrology 11, 658-668

Charonis AS, Sideraki V, Kaltezioti V, Alberti A, Vlahakos D, Wu K, Tsilibary EC (2005). Basement membrane peptides: functional considerations and biomedical applications in autoimmunity. Current Medicinal Chemistry, 12, 1495-1502

Kypreou K, Kavvadas P, Karamessinis P, Peroulis M, Alberti A, Sideras P, Psarras S, Capetanaki Y, Politis P, Charonis AS (2008). Altered expression of calreticulin during the development of fibrosis. Proteomics, 8, 2407-2419

Vlahou et al (88 names including Charonis A). Establishment of a European Network for Urine and Kidney Proteomics (2008). J. Proteomics 71:490-492

Alberti A, Karamessinis P, Peroulis M, Kypreou K, Kavvadas P, Pagakis S, Politis P, Charonis AS (2009). Erp46 is reduced by high glucose and regulares insulin content in pancreatic beta cells. Am. J. Physiol. Endocrin. Metab. 297:E812-E821

Vlahou A, Charonis A, Benigni A (2009). Report on the first combined working group and management committee meeting of EuroKUP. J. Proteomics 71:682-684

Brief Description

Dr. Aristidis Charonis holds an M.D. degree from the University of Athens and a Ph.D. degree from the University of California San Francisco. He is currently Chief Researcher at the Biomedical Research Foundation of the Academy of Athens and Director of the Section of Histology and the Histochemistry Core Facility.
Dr. Charonis’s past work focused on the structure and function of extracellular matrix macromolecules in health and disease, with emphasis on kidney diseases. His early work focused on laminin, studying its properties of self-assembly and interaction with other extracellular macromolecules and cell surface receptors and mapping interaction sites. Diabetic modifications of laminin and kidney basement membranes were also studied, along with their influence in cellular phenotype. Subsequently,, the focus of his work was on a novel basement membrane macromolecule, tubulointerstitial nephritis antigen (TIN-ag). Following cloning of TIN-ag, structural and functional analysis of its domains and regulation of its expression were being investigated.
Dr. Charonis’s recent work aims at understanding the process of fibrosis at the molecular level. His team is using proteomic approaches in order to identify crucial macromolecules involved in fibrotic processes. His main focus is kidney fibrosis and he is using the unilateral ureteric obstruction rat model. Based on recent proteomic data, he is focusing on two potentially important macromolecules for renal fibrosis, calreticulin and transgelin. Ongoing work in his laboratory focuses on the mechanisms involving calreticulin and transgelin in the development of fibrosis and on the possibility of using these macromolecules in order to better diagnose renal diseases. He is also interested in diabetes and its complications and more specifically in the molecular mechanisms by which glucose toxicity affects the function of pancreatic beta cells.

Contact Information

Phone

+30-210-6597205

Fax

+30-210-6597545

Email

acharonis(at)bioacademy(dot)gr

History

Member for

2 years 9 weeks