Profile

Title

PhD, Full Professor of Physiology

Full name

José M. Lopez-Novoa

Affiliation

Renal and cardiovascular Physiopathology Unit
Department of Physiology and Pharmacology,
Faculty of Medicine,
University of Salamanca,
Campus Miguel de Unamuno
E-37007 Salamanca, Spain

Working group 3

Keywords

Mechanisms underlying renal fibrosis, Renal toxicity of drugs and heavy metals, Arterial pressure regulation, Inflammation in renal disease, Predictive and prognostic urinary biomarkers

Publications

Sauzeau V, Sevilla MA, Rivas-Elena JV, de Alava E, Montero MJ, Lopez-Novoa JM, Bustelo XR. Vav3 proto-oncogene deficiency leads to sympathetic hyperactivity and cardiovascular dysfunction. Nature Medicine 2006 Jul;12(7):841-5.

Perez-Rivero G, Ruiz-Torres MP, Rivas-Elena JV, Jerkic M, Diez-Marques ML, Lopez-Novoa JM, Blasco MA, Rodriguez-Puyol D. Mice deficient in telomerase activity develop hypertension because of an excess of endothelin production. Circulation. 2006 Jul 25;114(4):309-17.

Jerkic M, Rivas-Elena JV, Santibanez JF, Prieto M, Rodriguez-Barbero A, Perez-Barriocanal F, Pericacho M, Arevalo M, Vary CP, Letarte M, Bernabeu C, Lopez-Novoa JM. Endoglin regulates cyclooxygenase-2 expression and activity. Circ Res. 2006 Aug 4;99(3):248-56.

Rodriguez-Barbero A, Dorado F, Velasco S, Pandiella A, Banas B, Lopez-Novoa JM. TGF-beta1 induces COX-2 expression and PGE2 synthesis through MAPK and PI3K pathways in human mesangial cells. Kidney Int. 2006 Sep;70(5):901-9.

Velasco S, Alvarez-Muñoz P, Pericacho M, Dijke PT, Bernabéu C, López-Novoa JM, Rodríguez-Barbero A. L- and S-endoglin differentially modulate TGF{beta}1 signaling mediated by ALK1 and ALK5 in L6E9 myoblasts. J Cell Sci. 2008 Mar 15;121(Pt 6):913-919.

Brief Description

Our Research Unit is located in Salamanca, an old university city in the center of Spain. The overall purpose of our research group is to deep into the knowledge of the mechanisms involved in the physiopathology of hypertension and renal diseases from an integrative point of view, using whole animal models, samples from patients and experimental animals, cell culture and molecular approaches. Our major present research topics are:
- Role of TGF-beta receptors (endoglin and Alk-1) in the regulation of vascular function and renal fibrosis
- Role of small GTPases of the Ras family in the regulation of vascular function and renal fibrosis.
- Pro-inflammatory effects of TGF-beta in mesangial cells.
- Mechanisms of toxic renal damage induced by cisplatin, gentamicin and heavy metals, and possible protective maneuvers.
- Search for new urinary markers of early renal damage (both toxic and acute).

We are expert in cardiovascular and renal function in whole animals (both by invasive and non-invasive methods in anaesthetized and awake rats and mice), histological and immunohistochemical studies, studies of cell biology in primary cell cultures or immortalized cell lines (proliferation, contraction, apoptosis, migration, extracellular matrix synthesis, etc.), cell transfection, shiRNA, basic molecular biology, and urinary proteomics.

Contact Information

Phone

+34 923294472

Fax

+34 923294669

Email

jmlnovoa(at)usal(dot)es

History

Member for

2 years 9 weeks