Profile

Title

Professor

Full name

Patrick C D'Haese

Affiliation

Laboratory of Pathophysiology – University of Antwerp

Working group 3

Management Committee

Keywords

urinary markers, nephrotoxicity, primary cell culture, (immuno-)histomorphometry, experimental animal models

Publications

R.P. Wedeen, S. Hague, I. Udasin, P.C. D'Haese, M. Elseviers, M.E. De Broe. Absence of tubular proteinuria following environmental exposure to chromium. Arch. Environm. Hlth. 51(4): 321-323, 1996.

A.R.J. Bervoets, G. Spasovski, G.J.S. Behets, G. Dams, M-M. Couttenye, M.E. De Broe, P.C. D’Haese. Usefulness biochemical markers for diagnosing renal osteodystrophy in pre-dialysis in end-stage renal failure patients. Am. J. Kidney Dis. 41(5): 997-1007, 2003.

P.C. D’Haese, G. B. Spasovski2, A. Sikole, A. Hutchison, T. J. Freemont, S. Sulkova, C. Swanepoel, S. Pejanovic7, L. Djukanovic, A. Balducci, G. Coen, W. Sulowicz, A. Ferreira, A. Torres, S. Curic, M. Popovic, N. Dimkovic, M. E. De Broe. A multi-centre study on the effects of lanthanum carbonate (FosrenolTM) and calcium carbonate on renal bone disease in dialysis patients. Kidney Int.63 (Suppl 85): S73-S78, 2003.

A. Verhulst, P.C. D’Haese, M.E. De Broe. Inhibitors of HMG-CoA reductase reduce receptor-mediated endocytosis in human kidney proximal tubular cells. J Am Soc Nephrol 15: 2249-2257, 2004.

E. Neven, S. Dauwe, M.E. De Broe, P.C. D’Haese. V. Persy. Endochondral bone formation is involved in the process of media calcification in rats and men Kidney Int 72: 574-582, 2007

Brief Description

Position:
Head of the Laboratory of Pathophysiology of the University of Antwerp, Belgium

Expertise:
- Analytical + clinical aspects of trace element accumulation/deficiency

- General anorganic toxicology & experimental (anorganic) pharmacotoxicology
- Laboratory techniques/analytical chemistry: atomic absorption spectrometry, laser capture microdissection, real time RT PCR, histomorphometry/immunohistochemistry bone and soft tissues, synchrotron-based XRF/-diffraction, 2D-proteomics, µ-tomography, routine lab techniques (ELISA, RIA, …)

- Development of and setting up cell biological/experimental studies using rat-mouse models of acute/chronic renal failure, renal osteodystrophy, vascular calcification, nephrocalcinosis

- Cell culture (primary cultures and cell lines): osteoblasts (derived from rat calvaria or rat bone marrow), renal cells (human), vascular smooth muscle cells (human), parathyroid cells (human)

- In vitro transport studies

- Development of methods and strategies for invasive and non-invasive diagnosis of renal osteodystrophy, evaluation of biochemical markers of renal bone disease.

- Renal osteodystrophy: quantitative bone histology, epidemiology

- Dialysis-related, occupational/environmental exposure to trace metals

- Epidemiological evaluaton/validation of early markers of renal failure (occupational/environmental settings)

- Design – coordination research projects and pre-clinical/clinical trials

Research Activities

- Bone metabolism
Effect of a number of factors on the in vitro bone formation.
Research on the effect of a calcimimeticum on the evolution of renal osteodystrophy.
Role of the osteoblast on the development of renal osteodystrophy. A proteomics approach.
Effect of the therapeutic use of lanthanum carbonate on the Ca-balance in comparison to other phosphate binding agents.
Drug discovery: Experimental research on the effect of a number of compounds in the prevention of osteoporosis in the rat.

- Vascular calcification.
In vitro en in vivo research on the mechanisms underlying the development vascular calcification in chronic renal failure.
Comparative studies on the effect of a number of pharmaca on the development/reversibility of vascular calcifications in the chronic renal failure rat.
The calcification paradox: Experimental research on the role of the bone turn-over on the development of vascular calcifications.

- Cell biology of nephrocalcinosis and nephrolithiasis.
Research on the role of the tubular phenotype and the expression of number of relevant molecules in the development of tubular crystal retention.
Research on the potential role and alternative use of already existing pharmaca in the prevention of nephrocalcinosis.

- In vitro research on the renal transport and potential toxic effects of various pharmaca.

- Cell biological and experimental research on the mechanisms underlying the protective effect of a new erythropoietin compound in chronic renal failure.

- Chinese herb nephropathy: An experimental approach.

- Epidemiological study on the cumulative toxic or protective effect of moderately increased multi-element exposure to heavy metals on a number of clinical/biochemical parameters.

- The effect of particular statins on the urinary proteome

Contact Information

Phone

+32/3/820.25.99

Fax

+32/3/820.25.92

Email

patrick.dhaese(at)ua(dot)ac(dot)be

History

Member for

3 years 30 weeks