Profile

Title

PhD

Full name

Jean-Loup Bascands

Affiliation

Inserm U858-I2MR-Equipe 5
1 avenue Jean Poulhès
B.P. 84225
31432 Toulouse Cedex 4
France

Working group 2

Keywords

Renal fibrosis, Pediatric kidney disease, chronic kidney disease, urinary proteomics, biomarkers

Publications

Jean-Philippe Pradère, Julie Klein, Sandra Grès, Charlotte Guigné, Eric Neau, Philippe Valet, Denis Calise, Jerold Chun, Jean-Loup Bascands, Jean-Sébastien Saulnier-Blache and Joost P. Schanstra. LPA1 receptor activation promotes renal interstitial fibrosis J Am Soc Nephrol. 2007 Dec;18(12):3110-8.

Decramer S, Wittke S, Mischak H, Zurbig P, Walden M, Bouissou F, Bascands JL, Schanstra JP. Predicting the clinical outcome of congenital unilateral ureteropelvic junction obstruction in newborn by urinary proteome analysis. Nat Med. 2006 Apr;12(4):398-400.

Schanstra JP, Neau E, Drogoz P, Arevalo Gomez MA, Lopez Novoa JM, Calise D, Pecher C, Bader M, Girolami JP, Bascands JL. In vivo bradykinin B2 receptor activation reduces renal fibrosis. J Clin Invest. 2002 Aug;110(3):371-9.

Marin-Castano ME, Schanstra JP, Neau E, Praddaude F, Pecher C, Ader JL, Girolami JP, Bascands JL. Induction of functional bradykinin b(1)-receptors in normotensive rats and mice under chronic Angiotensin-converting enzyme inhibitor treatment. Circulation. 2002 Feb 5;105(5):627-32.

Schanstra JP, Bataille E, Marin Castano ME, Barascud Y, Hirtz C, Pesquero JB, Pecher C, Gauthier F, Girolami JP, Bascands JL. The B1-agonist [des-Arg10]-kallidin activates transcription factor NF-kappaB and induces homologous upregulation of the bradykinin B1-receptor in cultured human lung fibroblasts. J Clin Invest. 1998 May 15;101(10):2080-91.

Brief Description

The objective of our research group is the development of new concepts of nephroprotection focussing on both interstitial fibrosis and glomerulosclerosis. We aim the improvement of early non-invasive diagnosis and prognosis of renal disease and the identification of nephroprotective molecules or therapies.

Contact Information

Phone

+33 5 61 32 37 48

Fax

+33 5 62 17 25 54

Email

Jean-loup.Bascands(at)inserm(dot)fr

History

Member for

3 years 30 weeks