Profile

Title

Head, Department of Molecular Medicine

Full name

Ariela Benigni

Affiliation

Istituto di Ricerche Farmacologiche Mario Negri

Management Committee

Keywords

Diabetes, Gene Therapy, Immunology, Animal Models, Chronic nephropathy

Publications

Morigi M, Imberti B, Zoja C, Corna D, Tomasoni S, Abbate M, Rottoli D, Angioletti S, Benigni A, Perico N, Alison M, Remuzzi G. Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure. J Am Soc Nephrol 15:1794-1804,2004.

Benigni A, Corna D, Zoja C, Longaretti L, Gagliardini E, Perico N, Coffman TM, Remuzzi G. Targeted deletion of angiotensin II type 1A receptor does not protect mice from progressive nephropathy of overload proteinuria. J Am Soc Nephrol 15:2666-2674, 2004.

Morigi M, Buelli S, Angioletti S, Zanchi C, Longaretti L, Zoja C, Galbusera M, Gastoldi S, Mundel P, Remuzzi G, Benigni A. In response to protien load podocytes reorganize cytoskeleton and modulate endothelin-1 gene. Am J Pathol 166:1309-1320, 2005.

Benigni A Tomasoni S, Turka LA, Longaretti L, Zentilin L, Mister M, Pezzotta A, Azzollini N, Noris M, Conti S, Abbate M, Giacca M, Remuzzi G. Adeno-associated virus-mediated CTLA4Ig gene transfer protects MHC-mismatched renal allografts from chronic rejection. J Am Soc Nephrol 17:1665-1672, 2006.

Benigni A, Caroli C, Longaretti L, Gagliardini E, Zoja C, Galbusera M, Moioli D, Romagnani P, Tincani A, Andreoli L, Remuzzi G. Involvment of renal tubular Toll-like receptor 9 in the development of tubulointerstitial injury in systemic lupus. Arthritis & Rheumatism 56:1569-1578, 2007.

Brief Description

Ariela Benigni got the Biol.Sci. degree in 1979 at the University of Milano, Italy, and the Ph.D. at Maastricht University, Netherlands.
Educational training: in 1979 Post Doctoral Fellow, Istituto di Ricerche Farmacologiche Mario Negri (IRFMN), Laboratory of Cancer Chemotherapy, Milan, Italy; in 1980-1981 Post Doctoral Fellow, Associazione Bergamasca per lo Studio delle Malattie Renali, Laboratory of the Division of Nephrology and Dialysis, Ospedali Riuniti di Bergamo, Italy; in 1982 Post Doctoral Fellow, Centre Regional de Transfusion Sanguigne de Strasbourg, France.
Areas of interest: vasoactive and inflammatory mediators of progressive renal injury with a particular emphasis on endothelin-1; combined treatment of antihypertensive and renoprotective drugs to halt progressive renal injury; use of stem cells for tissue regeneration in acute and chronic renal failure, in vivo e in vitro gene transfer to the kidney; prevention of acute graft rejection through gene therapy; induction of kidney transplant tolerance by gene therapy.
Employement: in 1983 Scientist, IRFMN, Laboratory of Kidney Disease, Bergamo, Italy; in 1990-1994 Head Laboratory of Prostaglandin and Leukotriene Metabolism, IRFMN, Bergamo, Italy; from January 1991 Scientific Secretary, IRFMN, Bergamo, Italy; in 1994-1999 Head Laboratory of Vasoactive and Inflammatory Mediators of Tissue damage, IRFMN, Bergamo, Italy; from January 2000 Head, Department of Molecular Medicine, IRFMN, Bergamo, Italy.

Contact Information

Phone

+39-035-319888

Fax

+39-035-319331

Email

abenigni(at)marionegri(dot)it

History

Member for

2 years 8 weeks