Profile

Title

Assoc. Prof. Dr.

Full name

Hassan Dihazi

Affiliation

Clinical Proteomics Laboratories
Nephrology & Rheumatology
Medical Center Goettingen
Georg-August University Goettingen
Robert-Koch Strasse 40
D-37075 Goettingen

Working group 2

Working group 3

Management Committee

Keywords

Urinary proteomics, Diabetic Nephropathy, renal fibrosis, UPR and ER-stress pathway

Publications

Dihazi H., Koziolek MJ., Söllner T., Kahler E., Klingel R., Neuhoff R., Strutz F., Mueller GA. Protein adsorption during LDL-apheresis: proteomic analysis. Nephrol. Dial. Transplant. 2008 Apr 8 [Epub ahead of print]

Dihazi H., Mueller GA., Lindner S., Meyer M., Asif AR., Oellerich M., and Strutz F. Characterization of diabetic nephropathy by urinary proteomic analysis: identification of a processed ubiquitin form as differentially excreted protein in diabetic nephropathy patients Clin. Chem. 2007 53(9):1636-45.

Dihazi H., Müller CA., Asif AR., Flad T., Müller GA. Whole cell profiling and identification of galectin-1 as a potential marker of renal cell carcinoma Proteomics-Clinical Applications 2007 1 (2): p 200-214.

Dihazi H., Müller GA. The urinary proteome: a tool to discover biomarker of kidney diseases Expert Rev Proteomics 2007 4(1):39-50.

Dihazi H, Asif AR, Agarwal NK, Doncheva Y, Müller GA Proteomics Analysis of Cellular Response to Osmotic Stress in TALH cells: Mol. Cell. Proteomics 2005 4 (10):1445-1458.

Brief Description

I have been a Group Leader of Proteomics at the Department of Nephrology and Rheumatology at the Georg-August University Goettingen since 2003. In 2006 I also became Director of the Clinical Proteomics Facility in the Medical Centre Goettingen at the same institution. Previously I worked as a scientist at the IZKF in Leipzig. Before that I was a postdoctoral fellow at the Biochemistry Institute at the University of Leipzig, where I received his PhD in Biochemistry.

We are focussing on identification and characterisation of the key proteins connecting ER-stress, oxidative stress and unfolded protein response pathways to renal diseases. We investigate the role of these stress pathway proteins in renal diseases progression. Furthermore, the impact of anti-stress based therapy on renal diseases progression is a very important part of our research field.
My group also seeks to develop new clinical proteomics approaches for earlier diagnosis of human diseases or for biomarker discovery. We have funded experience in proteomics analysis of tissue and body fluids (urine, dialysate, plasma, serum, synovial fluid)
I am a council member of the Human Kidney and Urine Proteomics Project, and the co-founder of the Goettingen Proteomics Forum.

Contact Information

Phone

+49-551-3991221

Fax

+49-551-3991039

Email

dihazi(at)med(dot)uni-goettingen(dot)de

Homepage

http://gwdu05.gwdg.de/~nephro//html/ag_dihazi.html

History

Member for

2 years 8 weeks