Profile

Title

Professor

Full name

Roz Banks

Affiliation

Clinical and Biomedical Proteomics Group
Cancer Research UK Clinical Centre
St James’s University Hospital,
Leeds LS9 7TF
UK

Working group 1

Working group 2

Working group 3

Keywords

Clinical proteomics, renal cancer, renal transplantation, kidney injury, biomarkers

Publications

(see www.proteomics.leeds.ac.uk for full list)

Nirmalan NJ, Harnden P, Selby PJ, Banks RE. Mining the archival formalin-fixed paraffin-embedded tissue proteome: opportunities and challenges. Mol Biosyst. 2008 4(7):712-720.

Craven RA, Stanley AJ, Hanrahan S, Dods J, Unwin R, Totty N, Harnden P, Eardley I, Selby PJ, Banks RE. Proteomic analysis of primary cell lines identifies protein changes present in renal cell carcinoma. Proteomics. 2006 6(9):2853-64.

Banks RE, Stanley AJ, Cairns DA, Barrett JH, Clarke P, Thompson D, Selby PJ. Influences of blood sample processing on low-molecular-weight proteome identified by surface-enhanced laser desorption/ionization mass spectrometry. Clin Chem. 2005 51(9):1637-49.

Rogers MA, Clarke P, Noble J, Munro NP, Paul A, Selby PJ, Banks RE. Proteomic profiling of urinary proteins in renal cancer by surface enhanced laser desorption ionization and neural-network analysis: identification of key issues affecting potential clinical utility. Cancer Res. 2003 63(20):6971-83.

Banks RE, Dunn MJ, Forbes MA, Stanley A, Pappin D, Naven T, Gough M, Harnden P, Selby PJ. The potential use of laser capture microdissection to selectively obtain distinct populations of cells for proteomic analysis--preliminary findings. Electrophoresis. 1999 20(4-5):689-700.

Brief Description

I am currently a Professor of Biomedical Proteomics at the University of Leeds based in the Cancer Research UK Clinical Centre. I am also a Committee member of the British Society for Proteome Research and on the Editorial Board of several journals including being a Senior Editor for Proteomics Clinical Applications. My research activities are focussed on using principally proteomics-based approaches to look for new biomarkers and therapeutic targets in disease (www.proteomics.leeds.ac.uk). Our major focus is in renal cancer where we also explore the pathology and biology underlying the disease but we also now have collaborative projects in renal medicine (renal transplant rejection and kidney injury) and neurology (multiple sclerosis) in addition to involvement in marker discovery for several national or international clinical trials. Underpinning this we have a major sample banking initiative (tissues and fluids). As part of our biomarker discovery programme we have particular interest in quality control including the influence of preanalytical factors and experimental design issues and are also now starting to address the issues of the most appropriate mechanisms for large scale evaluation of potential markers and liaison with diagnostics companies to ensure translation to the clinic which is a major challenge in the biomarker pipeline. The group is multidisciplinary and includes research nurses, technicians, clinical biochemists, research students (clinical and non-clinical) and postdoctoral fellows with wide-ranging skills including bioinformatics, biostatistics, mass spectrometry, cell biology and biochemistry. We have very well-equipped labs with mass spectrometry (QSTAR and SELDI currently), HPLC and 2D DIGE featuring heavily and after promising pilot data hope to be able to investigate imaging mass spectrometry further in the future subject to funding! Our current funding sources include a programme grant and project grants from Cancer Research UK and grants from DIUS, Dept of Health, MRC, AstraZeneca, Kidney Research UK and the KTP scheme.

Contact Information

Phone

+44 113 2064927

Fax

+44 113 2429886

Email

r.banks(at)leeds(dot)ac(dot)uk

Homepage

http://www.proteomics.leeds.ac.uk

History

Member for

2 years 6 weeks