Profile

Title

MD, PhD

Full name

Alberto Ortiz

Affiliation

Fundacion Jimenez Diaz, Madrid, Spain

Working group 1

Keywords

Acute kidney injury, chronic kidney disease, apoptosis, inflammation, fibrosis

Publications

Justo P, Sanz AB, Egido J, Ortiz A. 3,4-di-deoxyglucosone-3-ene induces apoptosis in renal tubular epithelial cells. Diabetes 2005;54:2424-9

Blanco-Colio LM, Martín-Ventura JL, Muñóz-García B, Orbe J, Páramo JA, Michel JB, Ortiz A, Meilhac O, Egido J. Identification of Soluble Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (sTWEAK) as a Possible Biomarker of Subclinical Atherosclerosis. Arterioscler Thromb Vasc Biol 2007;27:916-22

Lorz C, Benito-Martín A, Boucherot A, Ucero AC, Rastaldi MP, Henger A, Armelloni S, Santamaría B, Kretzler M, Egido J, Ortiz A. The death ligand TRAIL in diabetic nephropathy. J Am Soc Nephrol. 2008, 19;904-14
Sanz AB, Justo P, Sanchez-Niño MD, Blanco-Colio LM, Winkles JA, Kreztler M, Jakubowski A, Egido J, Ruiz-Ortega M, Ortiz A. The Cytokine TWEAK Modulates Renal Tubulointerstitial Inflammation. J Am Soc Nephrol. 2008;19:695-703

Sanchez-Niño MD, Sanz AB, Ihalmo P, Lassila M, Holthofer H, Mezzano S, Aros C, Groop PH, Saleem MA, Mathieson PW, Langham R, Kretzler M, Nair V, Lemley KV, Nelson RG, Mervaala E, Mattinzoli D, Rastaldi MP, Ruiz-Ortega M, Martin-Ventura JL, Egido J, Ortiz A. The MIF receptor CD74 in diabetic podocyte injury. J Am Soc Nephrol 2008 (in press)

Brief Description

1. Integrated in RedinRen (Spanish renal research network), which is building a CKD biobank
2. Diabetic nephropathy: from the human DN transcriptome to new biomarkers and therapeutic targets: a long-standing collaboration with Matthias Kretzler (now at U of Michigan). Our group provides animal models and functional cell culture (podocyte, tubular cell) and animal studies. Focus on cell death and inflammation
3. Acute kidney injury: role of cell death and inflammation, search for new therapeutic targets
4. Influence of glucose and glucose degradation products on cell biology
5. Peritoneal dialysis: local and systemic effects of PD solutions
6. Biology of TWEAK/Fn14: involvement in cell death, cell proliferation, inflammation and fibrosis, role in podocyte, tubular cell and fibroblast biology
7. Animal models: murine folic-acid nephropathy, unilateral ureteral obstruction and renal ischemia-reperfusion, streptozotocin induced diabetes, uninephrectomized spontaneously hypertensive rats

Contact Information

Phone

+34655538941

Email

aortiz(at)fjd(dot)es

History

Member for

1 year 48 weeks